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Michael Lefevre

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Nutrition, Dietetics and Food Sciences

Gut Health, Diet and Chronic Disease Risk, Dietary Bioactives, Clinical Trialss

Professor

Contact Information

Office Hours: By Appointment
Go toOffice Location: USTAR 650
DialPhone: 435-797-3821
SendEmail: michael.lefevre@usu.edu


Educational Background

PhD, Nutrition, (Physilogical Sciences), University of California, Davis, 1981
Elastin metabolism in avian lung and aorta: Effect of selected nutritional factors
BS, Nutrition, University of California, Davis, 1977

Teaching Interests

Methods in nutrition research

Research Interests

Diet and chronic disease; Personalized nutrition; Diet and intestinal microbiota

Awards

Fellow

American Hearth Association

Publications - Abstracts

    Publications - Books & Book Chapters

      * Has not been peer reviewed

      Publications - Fact Sheets

        * Has not been peer reviewed

        Publications - Curriculum

          * Has not been peer reviewed

          Publications - Journal Articles

            Academic Journal

          • Stevens, J.R, Jones, T.R, Lefevre, M., Ganesan, B., Weimer, B.C, (2017). SigTree: a microbial community analysis tool to identify and visualize significantly responsive branches in a phylogenetic tree. Computational and Structural Biotechnology Journal, 15, 372-378. doi: 10.1016/j.csbj.2017.06.002
          • Monsanto, S.P, Hintze, K.J, Ward, R.E, Larson, D.P, Lefevre, M., Benninghoff, A., (2016). The new total Western diet for rodents does not induce an overweight phenotype or alter parameters of metabolic syndrome in mice. Nutrition Research, 36:9, 1031-1044. doi: 10.1016/j.nutres.2016.06.002
          • Benninghoff, A., Lefevre, M., Hintze, K.J, Ward, R.E, Broadbent, J.R, (2015). Fighting cancer with functional foods: new approaches to investigate the interactions of dietary bioactive chemicals and the gut microbiome. Journal of Developments in Sustainable Agriculture, 10:1, 34-54. doi: 10.11178/jdsa.10.34
          • Zhou, A.L, Hergert, N., Rompato, G., Lefevre, M., (2015). Whole grain oats improve insulin sensitivity and plasma cholesterol profile and modify gut microbiota composition in C57BL/6J mice. Journal of Nutrition, 145, 222-230. doi: 10.3945/jn.114.199778
          • Porcellato, D.C, Brighton, C., McMahon, D.J, Oberg, C.J, Lefevre, M., Broadbent, J.R, Steele, J.L, (2014). Application of ARISA to assess the influence of salt content and cation type on microbiological diversity of Cheddar cheese.. Lett. Applied Microbiol., 59, 207-216. doi: 10.1111/lam.12263
          • Aguilar, S., Wengreen, H., Lefevre, M., Madden, G., Gast, J.A, (2014). Skin carotenoids: A biomarker of fruit and vegetable intake in children.. Journal of the Academy of Nutrition and Dietetics, 114:8, 1174-1180.
          • Lee, B., Lee, M., Lefevre, M., Kim, H.R, (2014). Anthocyanins inhibit lipogenesis during adipocyte differentiation of 3T3-L1 preadipocytes. Plant Foods Human Nutrition, 69, 137-141. doi: 10.1007/s11130-014-0407-z
          • Hintze, K.J, Lefevre, M., Ward, R.E, Benninghoff, A., Broadbent, J.R, Cox, J., (2014). Broad scope method for creating humanized animal models for animal health and disease research through antibiotic treatment and human fecal transfer. Gut Microbiology, 5, 183-191. doi: 10.4161/gmic.28403
          • Hill, A.M, Funk, M.K, Steward, P.W, Kris-Etherton, P.M, Ginsberg, H.N, Tracy, R.P, Pearson, T.A, Lefevre, M., Reed, R.G, Elmer, P.J, Holleran, S., Ershow, A.G, (2014). Monthly hemostatic factor variability in women and men. Eur. J. Clin. Nutr, doi: 10.1111/eci.12235
          • Aguilar, S., Wengreen, H., Lefevre, M., Madden, G., (2013). Skin carotenoids as a biomarker for fruit and vegetable intake in children.. Journal of Nutrition Education and Behavior, 45, S66-67.
          • Lefevre, M., Mensink, R.P, Kris-Ehterton, P.M, Petersen, B., Smith, K., Flickinger, B.D, (2012). Predicted changes in fatty acid intakes, plasma lipids, and cardiovascular disease risk following replacement of trans fatty acid-containing soybean oil with application-appropriate alternatives. Lipids, 47, 951-962. doi: 10.1007/s11745-012-3705-y
          • Kris-Etherton, P.M, Lefevre, M., Mensink, R.P, Petersen, B., Flickinger, B.D, (2012). Trans fatty acid intakes and food sources in the U.S. Population: NHANES 1999–2002. Lipids, 47, 931-940. doi: 10.1007/s11745-012-3704-z
          • Lefevre, M., Jonnalagadda, S., (2012). Effect of whole grains on markers of subclinical inflammation. Nutrition Reviews, 70, 387-396. doi: 10.1111/j.1753-4887.2012.00487.x
          • Lin, X., Racette, S.B, Lefevre, M., Ma, L., Spearie, C.A, Steger-May, K., Ostlund, R.E, (2011). Combined effects of ezetimibe and phytosterols on cholesterol metabolism: A controlled feeding study. Circulation, 124, 596-601. doi: 10.1161/CIRCULATIONAHA.110.006692
          • Lin, X., Racette, S.B, Lefevre, M., Spearie, C.A, Most, M., Ma, L., Ostlund, R.E, (2010). The effects of phytosterols present in natural food matrices on cholesterol metabolism and LDL-cholesterol: A controlled feeding trial. Eur J Clin Nutr, 64:12, 1481-7. doi: 10.1038/ejcn.2010.180
          • Racette, S.B, Lin, X., Lefevre, M., Spearie, C.A, Ma, L., Osltund, R.E, (2010). Dose effects of dietary phytosterols on cholesterol metabolism: a controlled feeding study. Am J Clin Nutr, 91:1, 32-38. doi: 10.3945/ajcn.2009.28070
          • Johnson, R.K, Appel, L.J, Brands, M., Howard, B.V, Lefevre, M., Lustig, R.H, Sacks, F., Steffen, L.M, Wylie-Rosett, J., (2009). Dietary sugars intake and cardiovascular health. A scientific statement from the American Heart Associaion. Circulation, 120:11, 1011-1020.
          • Gao, Z., Yin, J., Zhang, J., Ward, R.E, Martin, R.J, Lefevre, M., Cefalu, W.T, Ye, J., (2009). Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes, 58:7, 1509-1517.
          • Rowe, S., Alexander, N., Clydesdale, F.M, Applebaum, R., Atkinson, S., Black, R., Dwyer, J., Hentges, E., Higley, N., Lefevre, M., Lupton, L., Miller, S., Tancredi, D., Weaver, C., Woteki, C., Wedral, E., (2009). Funding food science and nutrition research: financial conflicts and scientific integrity. J Nutr, 139:6, 1051-3.
          • Rowe, S., Alexander, N., Clydesdale, F.M, Applebaum, R., Atkinson, S., Black, R., Dwyer, J., Hentges, E., Higley, N., Lefevre, M., Lupton, L., Miller, S., Tancredi, D., Weaver, C., Woteki, C., Wedral, E., (2009). Funding food science and nutrition research: financial conflicts and scientific integrity. Nutr Rev, 67:5, 264-72.
          • Rowe, S., Alexander, N., Clydesdale, F.M, Applebaum, R., Atkinson, S., Black, R., Dwyer, J., Hentges, E., Higley, N., Lefevre, M., Lupton, L., Miller, S., Tancredi, D., Weaver, C., Woteki, C., Wedral, E., (2009). Funding food science and nutrition research: financial conflicts and scientific integrity. Am J Clin Nutr, 89:5, 264-72.
          • Hilpert, K.F, West, S.G, Bagshaw, D.M, Fishell, V., Barnhart, L., Lefevre, M., Most, M.M, Zemel, M.B, Chow, M., Hinderliter, A.L, Kittleson, J., Kris-Etherton, P.M, (2009). Effects of dairy products on intracellular calcium and blood pressure in adults with essential hypertension. J Am Coll Nutr, 28:2, 142-149.
          • Lefevre, M., Redman, L.M, Heilbronn, L.K, Smith, J.V, Martin, C.K, Rood, J.C, Greenway, F.L, Williamson, D.A, Smith, S.R, Ravussin, E., (2009). Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals. Atherosclerosis, 203, 206-213.
          • Harris, W.S, Mozaffarian, D., Lefevre, M., Toner, C.D, Colombo, J., Cunnane, S.C, Holden, J.M, Klurfeld, D.M, Morris, M.C, Whelan, J., (2009). Towards establishing dietary reference intakes for long-chain omega-3 fatty acids. J Nutr, 139:4, 804S-819S.
          • Lefevre, M., Wiles, J.E, Zhang, X., Howard, L.R, Gupta, S., Smith, A.A, Ju, Z.Y, DeLany, J.P, (2008). Gene expression microarray analysis of the effects of grape anthocyanins in mice �A test of an hypothesis generating paradigm. Metabolism, 57, S52-S57.
          • Larson-Meyer, D.E, Newcomer, B.R, Heilbronn, L.K, Volaufova, J., Smith, S.R, Alfonso, A.J, Lefevre, M., Rood, J.C, Williamson, D.A, Ravussin, E., (2008). Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function. Obesity, 16:6, 1355-62.
          • Cefalu, W.T, Ye, J., Zuberi, A., Rubnicky, D.M, Raskin, I., Liu, Z., Wang, Z.Q, Brantly, P.J, Howard, L., Lefevre, M., (2008). Botanicals and the metabolic syndrome. Am J Clin Nutr, 87:2, 481S-487S.
          • Mathivanan, S., Lefevre, M., et al (123 authors), , (2008). Human proteinpedia enables sharing of human protein data. Nat Biotechnol, 26:2, 164-167.
          • Berglund, L.M, Lefevre, M., Ginsberg, H.N, Kris-Etherton, P.M, Elmer, P.J, Stewart, P.W, Eershow, A., Pearson, T.A, Dennis, B.H, Roheim, P.S, Ramakrishnan, R., Reed, R., Stewart, K., Phillips, K.M, (2007). Comparison of monounsaturated fat versus carbohydrate as replacement for saturated fat in subjects with a high metabolic risk profile: studies in the fasting and postprandial state. Am J Clin Nutr, 86:6, 1611-20.
          • Wilson, J.B, Welsch, M., Allen, J., Thomson, J., Tulley, R., Lefevre, M., (2007). The association of homocysteine and related factors to brachial artery diameter and flow-mediated dilation. Metabolosm, 56:5, 641-8.
          • Gao, Z., Wang, Z., Zhang, X., Butler, A.A, Zuberi, A., Gawronska-Kozak, B., Lefevre, M., York, D.A, Ravussin, E., Berthoud, H.R, McGuinness, O., Cefalu, W.T, Ye, J., (2007). Inactivation of PKC-theta leads to increased susceptibility to obesity and dietary insulin resistance in mice. Am J Physiol-Endocrin Metab, 292:1, E-84-91.
          • Zvonic, S., Lefevre, M., Kilroy, G., Floyd, Z.E, DeLany, J.P, Kheterpal, I., Gravois, A., Dow, R., White, A., Wu, X., Gimble, J.M, (2007). Secretome of primary cultures of human adipose-derived stem cells (ASCs): Modulation of serpins by adipogenesis. Mol Cell Proteomics, 6:1, 18-28.
          • Lichtenstein, A.H, Appel, L.J, Brands, M., Carnethon, M., Daniels, S., Franch, H.A, Franklin, B., Kris-Ehterton, P., Harris, W.S, Howard, B., Karanja, N., Lefevre, M., Rudel, L., Sacks, F., Van Horn, L., Winston, M., Wylie-Rosett, J., (2006). Summary of American Association Diet and Lifestyle recommendations revision 2006. Arterisocler Thromb Vasc Biol, 26:10, 2186-91.
          • Lee, J., Bricker, T.M, Lefevre, M., Pinson, S.R, Oard, J.H, (2006). Proteomic and genetic approaches to identifying defense-related proteins in rice challenged with the fungal pathogen Rhizoctonia solani. Molecular Plant Pathology, 7:5, 2186-91.
          • Lichtenstein, A.H, Appel, L.J, Brands, M., Carnethon, M., Daniels, S., Franch, H.A, Franklin, B., Kris-Ehterton, P., Harris, W.S, Howard, B., Karanja, N., Lefevre, M., Rudel, L., Sacks, F., Van Horn, L., Winston, M., Wylie-Rosett, J., (2006). Diet and lifestyle recommendations revision 2006. A scientific statement from the American Heart Association Nutrition Committee. Circulation, 114:1, 82-96.
          • Professional Journal

          • Norton, M.C, Clark, C.J, Tschanz, J.T, Hartin, P., Fauth, E.B, Gast, J.A, Dorsch, T., Wengreen, H., Nugent, C., Robinson, W., Lefevre, M., McClean, S., Cleland, I., Schaefer, S., Aguilar, S., (2015). The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer’s disease risk: the Gray Matters randomized trial. Alzheimers & Dementia: Translational Research & Clinical Interventions, 1:1, 53-62. doi: doi:10.1016/j.trci.2015.05.001

          * Has not been peer reviewed

          Publications - Literary Journal

            * Has not been peer reviewed

            Publications - MultiMedia

              * Has not been peer reviewed

              Publications - Technical Reports

                * Has not been peer reviewed

                Publications - Translations & Transcripts

                  Publications - Other

                    * Has not been peer reviewed

                    Scheduled Teaching

                    NDFS 7800 - Seminar, Spring 2018

                    NDFS 5310, 6310 - Fundamentals of Nutrition Research, Fall 2017

                    NDFS 7800 - Seminar, Fall 2017

                    NDFS 7800 - Seminar, Spring 2017

                    NDFS 5310, 6310 - Fundamentals of Nutrition Research, Fall 2016

                    NDFS 7800 - Seminar, Fall 2016

                    NDFS 7800 - Seminar, Spring 2016

                    NDFS 3110 - Food, Technology, and Health, Fall 2014


                    Graduate Students Mentored

                    Kristina Farnsworth, Nutrition, Dietetics and Food Sciences, August 2013
                    Justin Bell, Nutrition, Dietetics and Food Sciences, September 2014 - August 2016