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Michael Lefevre

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Nutrition, Dietetics and Food Sciences

Gut Health, Diet and Chronic Disease Risk, Dietary Bioactives, Clinical Trialss

Professor

Educational Background

PhD, Nutrition, (Physilogical Sciences), University of California, Davis, 1981
Elastin metabolism in avian lung and aorta: Effect of selected nutritional factors
BS, Nutrition, University of California, Davis, 1977



Teaching Interests

Methods in nutrition research

Research Interests

Diet and chronic disease; Personalized nutrition; Diet and intestinal microbiota


Contact Information

Office Hours: By Appointment
Go toOffice Location: USTAR 650
DialPhone: 435-797-3821
SendEmail: michael.lefevre@usu.edu

Awards

Fellow

American Hearth Association

    Publications - Books & Book Chapters

      * Has not been peer reviewed

      Publications - Fact Sheets

        * Has not been peer reviewed

        Publications - Curriculum

          * Has not been peer reviewed

          Publications - Journal Articles

            Academic Journal

          • Monsanto, S.P, Hintze, K.J, Ward, R.E, Larson, D.P, Lefevre, M., Benninghoff, A., (2016). The new total Western diet for rodents does not induce an overweight phenotype or alter parameters of metabolic syndrome in mice. Nutrition Research, 36:9, 1031-1044. doi: 10.1016/j.nutres.2016.06.002
          • Benninghoff, A., Lefevre, M., Hintze, K.J, Ward, R.E, Broadbent, J.R, (2015). Fighting cancer with functional foods: new approaches to investigate the interactions of dietary bioactive chemicals and the gut microbiome. Journal of Developments in Sustainable Agriculture, 10:1, 34-54. doi: 10.11178/jdsa.10.34
          • Zhou, A.L, Hergert, N., Rompato, G., Lefevre, M., (2015). Whole grain oats improve insulin sensitivity and plasma cholesterol profile and modify gut microbiota composition in C57BL/6J mice. Journal of Nutrition, 145, 222-230. doi: 10.3945/jn.114.199778
          • Porcellato, D.C, Brighton, C., McMahon, D.J, Oberg, C.J, Lefevre, M., Broadbent, J.R, Steele, J.L, (2014). Application of ARISA to assess the influence of salt content and cation type on microbiological diversity of Cheddar cheese.. Lett. Applied Microbiol., 59, 207-216. doi: 10.1111/lam.12263
          • Aguilar, S., Wengreen, H., Lefevre, M., Madden, G., Gast, J.A, (2014). Skin carotenoids: A biomarker of fruit and vegetable intake in children.. Journal of the Academy of Nutrition and Dietetics, 114:8, 1174-1180.
          • Lee, B., Lee, M., Lefevre, M., Kim, H.R, (2014). Anthocyanins inhibit lipogenesis during adipocyte differentiation of 3T3-L1 preadipocytes. Plant Foods Human Nutrition, 69, 137-141. doi: 10.1007/s11130-014-0407-z
          • Hintze, K.J, Lefevre, M., Ward, R.E, Benninghoff, A., Broadbent, J.R, Cox, J., (2014). Broad scope method for creating humanized animal models for animal health and disease research through antibiotic treatment and human fecal transfer. Gut Microbiology, 5, 183-191. doi: 10.4161/gmic.28403
          • Hill, A.M, Funk, M.K, Steward, P.W, Kris-Etherton, P.M, Ginsberg, H.N, Tracy, R.P, Pearson, T.A, Lefevre, M., Reed, R.G, Elmer, P.J, Holleran, S., Ershow, A.G, (2014). Monthly hemostatic factor variability in women and men. Eur. J. Clin. Nutr, doi: 10.1111/eci.12235
          • Aguilar, S., Wengreen, H., Lefevre, M., Madden, G., (2013). Skin carotenoids as a biomarker for fruit and vegetable intake in children.. Journal of Nutrition Education and Behavior, 45, S66-67.
          • Lefevre, M., Mensink, R.P, Kris-Ehterton, P.M, Petersen, B., Smith, K., Flickinger, B.D, (2012). Predicted changes in fatty acid intakes, plasma lipids, and cardiovascular disease risk following replacement of trans fatty acid-containing soybean oil with application-appropriate alternatives. Lipids, 47, 951-962. doi: 10.1007/s11745-012-3705-y
          • Kris-Etherton, P.M, Lefevre, M., Mensink, R.P, Petersen, B., Flickinger, B.D, (2012). Trans fatty acid intakes and food sources in the U.S. Population: NHANES 1999–2002. Lipids, 47, 931-940. doi: 10.1007/s11745-012-3704-z
          • Lefevre, M., Jonnalagadda, S., (2012). Effect of whole grains on markers of subclinical inflammation. Nutrition Reviews, 70, 387-396. doi: 10.1111/j.1753-4887.2012.00487.x
          • Lin, X., Racette, S.B, Lefevre, M., Ma, L., Spearie, C.A, Steger-May, K., Ostlund, R.E, (2011). Combined effects of ezetimibe and phytosterols on cholesterol metabolism: A controlled feeding study. Circulation, 124, 596-601. doi: 10.1161/CIRCULATIONAHA.110.006692
          • Lin, X., Racette, S.B, Lefevre, M., Spearie, C.A, Most, M., Ma, L., Ostlund, R.E, (2010). The effects of phytosterols present in natural food matrices on cholesterol metabolism and LDL-cholesterol: A controlled feeding trial. Eur J Clin Nutr, 64:12, 1481-7. doi: 10.1038/ejcn.2010.180
          • Racette, S.B, Lin, X., Lefevre, M., Spearie, C.A, Ma, L., Osltund, R.E, (2010). Dose effects of dietary phytosterols on cholesterol metabolism: a controlled feeding study. Am J Clin Nutr, 91:1, 32-38. doi: 10.3945/ajcn.2009.28070
          • Johnson, R.K, Appel, L.J, Brands, M., Howard, B.V, Lefevre, M., Lustig, R.H, Sacks, F., Steffen, L.M, Wylie-Rosett, J., (2009). Dietary sugars intake and cardiovascular health. A scientific statement from the American Heart Associaion. Circulation, 120:11, 1011-1020.
          • Gao, Z., Yin, J., Zhang, J., Ward, R.E, Martin, R.J, Lefevre, M., Cefalu, W.T, Ye, J., (2009). Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes, 58:7, 1509-1517.
          • Rowe, S., Alexander, N., Clydesdale, F.M, Applebaum, R., Atkinson, S., Black, R., Dwyer, J., Hentges, E., Higley, N., Lefevre, M., Lupton, L., Miller, S., Tancredi, D., Weaver, C., Woteki, C., Wedral, E., (2009). Funding food science and nutrition research: financial conflicts and scientific integrity. J Nutr, 139:6, 1051-3.
          • Rowe, S., Alexander, N., Clydesdale, F.M, Applebaum, R., Atkinson, S., Black, R., Dwyer, J., Hentges, E., Higley, N., Lefevre, M., Lupton, L., Miller, S., Tancredi, D., Weaver, C., Woteki, C., Wedral, E., (2009). Funding food science and nutrition research: financial conflicts and scientific integrity. Am J Clin Nutr, 89:5, 264-72.
          • Rowe, S., Alexander, N., Clydesdale, F.M, Applebaum, R., Atkinson, S., Black, R., Dwyer, J., Hentges, E., Higley, N., Lefevre, M., Lupton, L., Miller, S., Tancredi, D., Weaver, C., Woteki, C., Wedral, E., (2009). Funding food science and nutrition research: financial conflicts and scientific integrity. Nutr Rev, 67:5, 264-72.
          • Hilpert, K.F, West, S.G, Bagshaw, D.M, Fishell, V., Barnhart, L., Lefevre, M., Most, M.M, Zemel, M.B, Chow, M., Hinderliter, A.L, Kittleson, J., Kris-Etherton, P.M, (2009). Effects of dairy products on intracellular calcium and blood pressure in adults with essential hypertension. J Am Coll Nutr, 28:2, 142-149.
          • Lefevre, M., Redman, L.M, Heilbronn, L.K, Smith, J.V, Martin, C.K, Rood, J.C, Greenway, F.L, Williamson, D.A, Smith, S.R, Ravussin, E., (2009). Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals. Atherosclerosis, 203, 206-213.
          • Harris, W.S, Mozaffarian, D., Lefevre, M., Toner, C.D, Colombo, J., Cunnane, S.C, Holden, J.M, Klurfeld, D.M, Morris, M.C, Whelan, J., (2009). Towards establishing dietary reference intakes for long-chain omega-3 fatty acids. J Nutr, 139:4, 804S-819S.
          • Lefevre, M., Wiles, J.E, Zhang, X., Howard, L.R, Gupta, S., Smith, A.A, Ju, Z.Y, DeLany, J.P, (2008). Gene expression microarray analysis of the effects of grape anthocyanins in mice �A test of an hypothesis generating paradigm. Metabolism, 57, S52-S57.
          • Larson-Meyer, D.E, Newcomer, B.R, Heilbronn, L.K, Volaufova, J., Smith, S.R, Alfonso, A.J, Lefevre, M., Rood, J.C, Williamson, D.A, Ravussin, E., (2008). Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function. Obesity, 16:6, 1355-62.
          • Cefalu, W.T, Ye, J., Zuberi, A., Rubnicky, D.M, Raskin, I., Liu, Z., Wang, Z.Q, Brantly, P.J, Howard, L., Lefevre, M., (2008). Botanicals and the metabolic syndrome. Am J Clin Nutr, 87:2, 481S-487S.
          • Mathivanan, S., Lefevre, M., et al (123 authors), , (2008). Human proteinpedia enables sharing of human protein data. Nat Biotechnol, 26:2, 164-167.
          • Berglund, L.M, Lefevre, M., Ginsberg, H.N, Kris-Etherton, P.M, Elmer, P.J, Stewart, P.W, Eershow, A., Pearson, T.A, Dennis, B.H, Roheim, P.S, Ramakrishnan, R., Reed, R., Stewart, K., Phillips, K.M, (2007). Comparison of monounsaturated fat versus carbohydrate as replacement for saturated fat in subjects with a high metabolic risk profile: studies in the fasting and postprandial state. Am J Clin Nutr, 86:6, 1611-20.
          • Wilson, J.B, Welsch, M., Allen, J., Thomson, J., Tulley, R., Lefevre, M., (2007). The association of homocysteine and related factors to brachial artery diameter and flow-mediated dilation. Metabolosm, 56:5, 641-8.
          • Gao, Z., Wang, Z., Zhang, X., Butler, A.A, Zuberi, A., Gawronska-Kozak, B., Lefevre, M., York, D.A, Ravussin, E., Berthoud, H.R, McGuinness, O., Cefalu, W.T, Ye, J., (2007). Inactivation of PKC-theta leads to increased susceptibility to obesity and dietary insulin resistance in mice. Am J Physiol-Endocrin Metab, 292:1, E-84-91.
          • Zvonic, S., Lefevre, M., Kilroy, G., Floyd, Z.E, DeLany, J.P, Kheterpal, I., Gravois, A., Dow, R., White, A., Wu, X., Gimble, J.M, (2007). Secretome of primary cultures of human adipose-derived stem cells (ASCs): Modulation of serpins by adipogenesis. Mol Cell Proteomics, 6:1, 18-28.
          • Lichtenstein, A.H, Appel, L.J, Brands, M., Carnethon, M., Daniels, S., Franch, H.A, Franklin, B., Kris-Ehterton, P., Harris, W.S, Howard, B., Karanja, N., Lefevre, M., Rudel, L., Sacks, F., Van Horn, L., Winston, M., Wylie-Rosett, J., (2006). Summary of American Association Diet and Lifestyle recommendations revision 2006. Arterisocler Thromb Vasc Biol, 26:10, 2186-91.
          • Lee, J., Bricker, T.M, Lefevre, M., Pinson, S.R, Oard, J.H, (2006). Proteomic and genetic approaches to identifying defense-related proteins in rice challenged with the fungal pathogen Rhizoctonia solani. Molecular Plant Pathology, 7:5, 2186-91.
          • Lichtenstein, A.H, Appel, L.J, Brands, M., Carnethon, M., Daniels, S., Franch, H.A, Franklin, B., Kris-Ehterton, P., Harris, W.S, Howard, B., Karanja, N., Lefevre, M., Rudel, L., Sacks, F., Van Horn, L., Winston, M., Wylie-Rosett, J., (2006). Diet and lifestyle recommendations revision 2006. A scientific statement from the American Heart Association Nutrition Committee. Circulation, 114:1, 82-96.
          • Professional Journal

          • Norton, M.C, Clark, C.J, Tschanz, J.T, Hartin, P., Fauth, E.B, Gast, J.A, Dorsch, T., Wengreen, H., Nugent, C., Robinson, W., Lefevre, M., McClean, S., Cleland, I., Schaefer, S., Aguilar, S., (2015). The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer’s disease risk: the Gray Matters randomized trial. Alzheimers & Dementia: Translational Research & Clinical Interventions, 1:1, 53-62. doi: doi:10.1016/j.trci.2015.05.001

          * Has not been peer reviewed

          Publications - Literary Journal

            * Has not been peer reviewed

            Publications - MultiMedia

              * Has not been peer reviewed

              Publications - Technical Reports

                * Has not been peer reviewed

                Publications - Translations & Transcripts

                  Publications - Other

                    * Has not been peer reviewed

                    Scheduled Teaching

                    NDFS 7800 - Seminar, Spring 2017

                    NDFS 5310, 6310 - Fundamentals of Nutrition Research, Fall 2016

                    NDFS 7800 - Seminar, Fall 2016

                    NDFS 7800 - Seminar, Spring 2016

                    NDFS 3110 - Food, Technology, and Health, Fall 2014


                    Graduate Students Mentored

                    Kristina Farnsworth, Nutrition, Dietetics and Food Sciences, August 2013
                    Justin Bell, Nutrition, Dietetics and Food Sciences, September 2014 - August 2016